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In rats the LOEL for induction periportal inflammation and periportal necrosis after acute DAP exposure was 300 mg/kg, in mice the LOEL was 700 mg/kg and the NOELwas 600 mg/kg. Within 24 hr after oral or i.v. dosing, rats excreted  25 -30% of the DAP as CO2, and 50-70% in urine, whereas mice excreted 6-12% of the DAP as CO2, and 80-90 % in the urine.Following i.v. administration of DAP, the parent compound was rapidly cleared from the blood of rats and mice. The t½ for elimination from blood was approximately 2 min in both species. No DAP was found in blood, liver, kidney, muscle, skin, or small intestine 30 min after iv administration of DAP. Major metabolites were monoallyl phthalate (MAP), allyl alcohol (AA), 3-hydroxypropylmercapturic acid(HPMA), and an unidentified polar metabolite were found in the urine of rats and mice dosed with DAP. Monoallyl phthalate, formed from the metabolism of DAP, had a half-life in blood of 32 and 9 min in rats and mice, respectively. The polar metabolite was also present in the urine of rats after administration of AA, indicating that the compound is a metabolite of AA. As mice produced more HPMA than rats the differential hepatotoxicity of DAP is related to the extent of gluthathione conjugation with AA or acrolein, the active metabolite of AA.