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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Diss Factsheets

Administrative data

Description of key information

Skin and Eye irritation studies were conducted on the analog source chemical n–butyl acrylate.  These results are considered to be appropriate for the target chemical 2-methylbutyl acrylate.
Skin Irritation:  Irritating
Eye Irritation:  Irritating

Key value for chemical safety assessment

Additional information

The Skin Irritation study was conducted by applying n-butyl acrylate to the skin of white rabbits for 1, 5, and 15 minutes in 2 animals. The test material was washed between applications. Additionally, 2 other animals had the test substance applied for 20 hours. In both cases, erythema and edema scores were greater than 2 and the erythema was not fully reversible within 8 days, which was the final day of the test.

 

Eye Irritation: 0.5 ml of the test substance was applied to 5 animals. 4 of 5 had moderate to severe injury, including 2 with iritis.

Data matrix – Analog approach

Target substance

Source substance (1)

 

CHEMICAL NAME

2-methylbutyl acrylate

n-butyl acrylate

 

CAS#

44914-03-6

141-32-2

 

Molecular formula

C8H14O2

C7H12O2

 

Molecular Weight

142.2

128.2

 

PHYSICO-CHEMICAL DATA     

Melting Point

Experimental:

≤ -75 °C

Not available

 

Boiling Point

Experimental:

161.7 °C at 1013hPa

Experimental:

147 °C at 1013hPa

 

Density

Experimental:

0.8886 g/cm3 at 25 °C

Experimental:

0.9 g/cm3 at 20.0 °C

 

Vapour Pressure

Experimental:

1.7 hPa at 20°C

Experimental:

5 hPa at 22.2°C

 

Partition Coefficient (log KOW)

Experimental:

2.9

Experimental:

2.38 (at 25°C)

 

Water Solubility

Experimental:

316 mg/L at 23 °C

Not available

 

MAMMALIAN TOXICITY

Skin Irritation

Readacross from source (1):

Irritating

Experimental:

Irritatiing

 

Eye Irritation

Readacross from source (1):

Irritating

Experimental:

Irritating

 

Justification for classification or non-classification

Skin and eye irritation scores meet the DSD and CLP criteria for classification as skin and eye irritation. 2-MBA is classified as Xi 36/37/38 down to 10% and as Skin Irr 2, Eye Irr 2 and STOT SE 3 H335( May cause respiratory irritation) down to 10%.