Registration Dossier
Registration Dossier
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EC number: 256-170-3 | CAS number: 44914-03-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Three studies have been conducted on the source chemical n-butyl acrylate and are considered to be appropriate for the target chemical 2-methylbutyl acrylate.
1. Relative Rates of hydrolysis of Butyl Acrylate Isomers by Mammalian Esterases:
Result: n-Butyl acrylate is rapidly hydrolized at rates between 54-79 micorgrams/min/mg protein after 2 minutes to 43-72 micrograms/min/mg protein.
2. In vivo toxicokinetics in rats via oral gavage
Result: n-Butyl acrylate is rapidly absorbed and metabolized. The acrylate moiety is primarily metabolized to CO2. n-Butyl acrylate is hydrolyzed to acrylic acid and butanol.
3. In vivo toxicokinetics in rats via iv.
Results: n-Butyl acrylate is rapidly absorbed and metabolized. The acrylate moiety is primarily metabolized to CO2. n-Butyl acrylate is hydrolyzed to acrylic acid and butanol. The compound and metabolites were cleared very rapidly and elimination decreased to almost negligible rates after 2 hours.
Key value for chemical safety assessment
Additional information
The source chemical n-butyl acrylate is absorbed and the major portion is hydrolyzed to acrylic acid, which is further metabolized to compounds available for oxidative metabolism. The target chemical 2-methybutyl acrylate is expected to follow the same pathway with the exception that 2- methylbutanol would be formed rather than n-butanol.
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