Registration Dossier
Registration Dossier
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EC number: 245-846-3 | CAS number: 23727-15-3
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- (-) CAMPHOLENIC ALDEHYDE is an isomer of (+) CAMPHOLENIC ALDEHYDE. Data on (+) CAMPHOLENIC ALDEHYDE can be extrapolated to (-) CAMPHOLENIC ALDEHYDE.
Cross-reference
- Reason / purpose for cross-reference:
- read-across source
Data source
Materials and methods
- Type of assay:
- other:
Test material
- Reference substance name:
- (S)-2,2,3-trimethylcyclopent-3-ene-1-acetaldehyde
- EC Number:
- 245-846-3
- EC Name:
- (S)-2,2,3-trimethylcyclopent-3-ene-1-acetaldehyde
- Cas Number:
- 23727-15-3
- Molecular formula:
- C10H16O
- IUPAC Name:
- 2-[(1S)-2,2,3-trimethylcyclopent-3-en-1-yl]acetaldehyde
- Details on test material:
- - Name of the test item (as cited in the study report): (-) CAMPHOLENIC ALDEHYDE
- IUPAC Name of the test item: (S)-2,2,3-trimethylcyclopenten-3-ene-1-acetaldehyde
- Substance type: monoconstituent
- Physical state: liquid
- Analytical purity: 87.1%
- Impurities (identity and concentrations): pinocamphone : 5.6%
- Purity test date: 2013-01-10
- Lot/batch No.: D60
- Expiration date of the lot/batch: January 2015
- Storage condition of test material: +2°C to +8°C, under nitrogen and protected from light
Constituent 1
Results and discussion
Test results
- Key result
- Species / strain:
- bacteria, other: Salmonella typhimurium and Escherichia coli
- Metabolic activation:
- not applicable
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- other: not applicable
- Vehicle controls validity:
- not applicable
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- not applicable
- Additional information on results:
- Mutagenicity in vitro in bacterium is INACTIVE: No misclassified or unclassified features
Mutagenicity in vitro in Escherichia coli is INACTIVE: No misclassified or unclassified features
Mutagenicity in vitro in Salmonella typhimurium is INACTIVE: No misclassified or unclassified features
Details
The query structure does not match any structural alerts or examples for (bacterial in vitro) mutagenicity in Derek. Additionally, the query structure does not contain any unclassified or misclassified features and is consequently predicted to be inactive in the bacterial in vitro (Ames) mutagenicity test.
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Conclusions:
- DEREK Nexus evaluation showed no alerts for mutagenicity in bacteria.
- Executive summary:
DEREK software ( Derek Nexus: 6.1.0, Nexus: 2.3.0, Lhasa Ltd.) was used to predict the mutagenicity of 2-[(1R)-2,2,3-trimethylcyclopent-3-en-1-yl]acetaldehyde.
The query structure does not match any structural alerts or examples for (bacterial in vitro) mutagenicity in Derek. Additionally, the query structure does not contain any unclassified or misclassified features and is consequently predicted to be inactive in the bacterial in vitro (Ames) mutagenicity test.
DEREK Nexus evaluation showed no alerts for mutagenicity in bacteria.
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