2-methoxyethyl 2-cyanoacrylate

Biodegradation in water: screening tests

Administrative data

Endpoint:

biodegradation in water: ready biodegradability

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Study period:

November 2013 - January 2014

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline study and GLP

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2014

Report date:

2014

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

2-methoxyethyl 2-cyanoacrylate

EC Number:

248-670-5

EC Name:

2-methoxyethyl 2-cyanoacrylate

Cas Number:

27816-23-5

Molecular formula:

C7H9NO3

IUPAC Name:

2-methoxyethyl 2-cyanoprop-2-enoate

Test material form:

liquid

Details on test material:

2-methoxyethyl 2-cyanoacrylate
Test Item name: SAT 130032
Batch: #L2PW120143

Study design

Oxygen conditions:

aerobic

Inoculum or test system:

activated sludge, domestic, non-adapted

Duration of test (contact time):

28 d

Results and discussion

% Degradation

Parameter:

% degradation (O2 consumption)

Value:

86

Sampling time:

28 d

Any other information on results incl. tables

The reference item sodium benzoate was sufficiently

degraded to 83% after 14 days and to 86% after 28 days

of incubation, thus confirming the suitability of the aerobic

activated sludge inoculum used.

In the toxicity control containing both, the test item and

the reference item sodium benzoate, 77% (ThODNH4)

biodegradation was noted within 14 days and 82%

(ThODNH4) biodegradation after 28 days of incubation

(67% and 71% based on ThODNO3). According to the

test guidelines, the test item can be assumed to be not

inhibitory to the aerobic activated sludge microorganisms

because degradation was >25% within 14 days.

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Interpretation of results:

readily biodegradable

Conclusions:

2-Methoxyethylcyanoacetate is considered to be readily biodegradable based on ThODNH4 / ThODNO3.

Executive summary:

The test item 2-Methoxyethylcyanoacetate contains

nitrogen; therefore the evaluation of biodegradation has

to be based ThODNH4 and ThODNO3. The criterion for

ready biodegradability under the conditions of a manometric

respirometry test is the 10-day window, describing

the period between reaching at least 10% degradation

and 60% degradation. This period should not exceed

10 days.

The mean biodegradation of 10% of 2-

Methoxyethylcyanoacetate was reached at day 3

(ThODNH4) and at day 4 (ThODNO3). At the end of the

10-day window at day 13 and day 14, the degradation of

2-Methoxyethylcyanoacetate was 109% (ThODNH4) and

84% (ThODNO3) and therefore the 10 day window criterion

was passed. The mean biodegradation at test end

after 28 days was 115% (ThODNH4) and 86% (ThODNO3).

Therefore, 2-Methoxyethylcyanoacetate is considered to

be readily biodegradable based on ThODNH4 / ThODNO3.