Registration Dossier
Registration Dossier
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EC number: 215-290-6 | CAS number: 1319-46-6
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Authoritative secondary source
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Approximately 100 pregnant female Long Evan rats received a diet containing 4% lead carbonate post partum. Offspring were sacrificed up to 71 days of age, having received 4% lead carbonate in the diet after cessation of suckling.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Trilead bis(carbonate) dihydroxide
- EC Number:
- 215-290-6
- EC Name:
- Trilead bis(carbonate) dihydroxide
- Cas Number:
- 1319-46-6
- Molecular formula:
- C2H2O8Pb3
- IUPAC Name:
- tris(λ²-lead(2+)) dihydroxide dicarbonate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Long-Evans
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 71 d
- Frequency of treatment:
- daily
- Duration of test:
- 71 d
Doses / concentrations
- Remarks:
- Doses / Concentrations:
4%
Basis:
nominal in diet
- No. of animals per sex per dose:
- 100 females post partum
Offsprings (number not reported) - Control animals:
- not specified
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:not examined
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:yes
Details on embryotoxic / teratogenic effects:
Retardation in growth
At 23–29 days of age approximately 90% of the offspring developed paraplegia for up to 2 weeks, with about 85%–90% of these animals dying
Histopathological changes were seen in the cerebellum indicative of encephalo-myelopathy
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The substance was found to be neurotoxic to the offsprings at the concentration tested
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