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Key value for chemical safety assessment

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The genotoxic profile of lead is mixed. Bacterial mutagenesis assays produce negative results while conflicting (positive and negative) observations have been made in mammalian cell mutagenesis systems. In the absence of confirmation that lead was in fact taken up by bacteria, negative results in bacterial systems will not be assigned significance in a weight of evidence evaluation.

Although lead may be capable of inducing genotoxicity by multiple mechanisms, it is not yet possible to ascertain which mechanism, or group of mechanisms, is of greatest importance and/or of physiological relevance in producing the spectrum of changes suggested by in vitro studies.

Short description of key information:
Although lead genotoxicity can be induced in vitro, responses appear to be induced by indirect mechanisms and at very high concentrations that lack physiological relevance.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification