Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-290-6 | CAS number: 1319-46-6
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Pulmonary retention of lead: an experimental study in man
- Author:
- Morrow PE, Beiter H, Amato F & Gibb FR
- Year:
- 1 980
- Bibliographic source:
- Environmental Research 21(2):373-384
Materials and methods
- Type of sensitisation studied:
- respiratory
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- After brief, mouthpiece exposures, 17 subjects were followed by serial counting with a thoracic array of 12 2-in. scintillation detectors and two 2-in. leg counters, all coupled to single channel analyzers.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Lead hydroxide
- EC Number:
- 243-310-3
- EC Name:
- Lead hydroxide
- Cas Number:
- 19783-14-3
- Molecular formula:
- H2O2Pb
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- confirmed and informed consent free of coercion received
- Subjects:
- - Number of subjects exposed: 2 groups of 4 and 5 persons each
- Sex: men
- Age: mean 26.5 (24-37)
- Other: mean weight 65.9 kg (55-86.4), mean height 1.75 m (1.65-1.85) - Clinical history:
- Young adults having no history of pulmonary disease
- Route of administration:
- inhalation
- Details on study design:
- TYPE AND DETAILS OF TEST(S) USED
- Lung function measurements: standard respiratory mouthpiece, deszigned so that the aerosol volume breathed was continuously measured using a recording integrator (Linear Instruments, Model 252A)
- Other: the exposure duration was predicated on the assumption that 100% deposition would occur
Results and discussion
- Results of examinations:
- The average aerosol deposition occuring in the nine lead hydroxide exposures was 26% (SD = 8). This resulted in 1.9 µCi 203Pb (0.7-3.2) and ~3 (1-5) micrograms of lead being deposited in the respiratory system of the average subject.
The measured (effective) halftime for retention of 950min (15.8h) for indicates a biological retention halftime of 22.6 h. Thus the correction factor reduces the biological half time approximately 40% (13.6 vs 22.6).
Any other information on results incl. tables
Urban air studies indicate atmospheric lead aerosol has a MMAD between 0.18 and 0.6 µm
Applicant's summary and conclusion
- Conclusions:
- The collective evidence supports the view that atmospheric lead is rapidly and completly absorbed from the human lungs.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
