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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study with acceptable restrictions
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1972
Report Date:
1972

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Study was performed acc. internal BASF method, which was in part equivalent to OECD Guideline 401
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Hydroxycitronellal (HCA); 3.7-Dimethyl-7-hydroxyoctanol-1
- Physical state: liquid
- Purity: approx. 99%

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: Gassner
- Weight at study initiation: mean: 268 g (male), 183 g (female)

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
CMC (carboxymethyl cellulose)
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 2%, 20%, 30%
- Other: vehicle solution contained 2-3 drops of cremophor EL (as solubilizer)
Doses:
200, 1600, 3200, 6400 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of weighing: prior to begin and at the end of study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Statistics:
Determination of the LD50 calculated according to Finney

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 6 400 mg/kg bw
Mortality:
200 mg/kg bw: 0/20 deahts
1600 mg/kg bw: 0/20 deaths
3200 mg/kg bw: 1/20 deaths; 1 male died within 48 h
6400 mg/kg bw: 0/20 deaths
Clinical signs:
Delayed and intermittent respiration, Dyspnea and atony
Gross pathology:
Enlarged stomach

Applicant's summary and conclusion