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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Publication which meets basic scientific principles, results in summary table only

Data source

Reference
Reference Type:
publication
Title:
Comparative studies on the irritancy of oils and synthetic perfumes to the skin of rabbit, guinea pig, rat, miniature swine and man
Author:
Motoyoshi K et al.
Year:
1979
Bibliographic source:
Cosmetics and Toiletries, 94(8), 41-48

Materials and methods

Endpoint addressed:
skin irritation / corrosion
Test guideline
Qualifier:
no guideline available
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Analytical purity: > 97 %

Method

Details on study design:
- Using a glass tuberculin syringe, 0.05 g of the test compound was transferred to the 15 mm patches which was then applied to the back of each subject for 48 hours.
- Patches were removed and sites swabbed with dry gauze to remove residual test material.
- Reactions were read 30 minutes after patch removal and if necessary at 72, 96, and 120 hours after patch removal
- Vehicle: acetone
- Concentration: 32%
Exposure assessment:
not specified

Results and discussion

Results:
Hydroxycitronellal was mildly irritating at 32% in acetone

Applicant's summary and conclusion