Registration Dossier
Registration Dossier
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EC number: 203-518-7 | CAS number: 107-75-5
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Publication which meets basic scientific principles, results in summary table only
Data source
Reference
- Reference Type:
- publication
- Title:
- Comparative studies on the irritancy of oils and synthetic perfumes to the skin of rabbit, guinea pig, rat, miniature swine and man
- Author:
- Motoyoshi K et al.
- Year:
- 1 979
- Bibliographic source:
- Cosmetics and Toiletries, 94(8), 41-48
Materials and methods
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 7-hydroxycitronellal
- EC Number:
- 203-518-7
- EC Name:
- 7-hydroxycitronellal
- Cas Number:
- 107-75-5
- Molecular formula:
- C10H20O2
- IUPAC Name:
- 7-hydroxy-3,7-dimethyloctanal
- Details on test material:
- - Analytical purity: > 97 %
Constituent 1
Method
- Details on study design:
- - Using a glass tuberculin syringe, 0.05 g of the test compound was transferred to the 15 mm patches which was then applied to the back of each subject for 48 hours.
- Patches were removed and sites swabbed with dry gauze to remove residual test material.
- Reactions were read 30 minutes after patch removal and if necessary at 72, 96, and 120 hours after patch removal
- Vehicle: acetone
- Concentration: 32% - Exposure assessment:
- not specified
Results and discussion
- Results:
- Hydroxycitronellal was mildly irritating at 32% in acetone
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
