Registration Dossier
Registration Dossier
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EC number: 939-524-8 | CAS number: 71949-28-5
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Unpublished report which meets generally accepted scientific standards, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
- Principles of method if other than guideline:
- Investigation of the absorption, distribution and excretion of the substance after a single cutaneous dose.
- GLP compliance:
- no
Test material
- Reference substance name:
- Reaction product of [29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]zinc, sulphuric acid and caustic soda
- EC Number:
- 939-524-8
- Cas Number:
- 71949-28-5
- Molecular formula:
- C32 H12 N8 O12 S4 Zn. 4Na
- IUPAC Name:
- Reaction product of [29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]zinc, sulphuric acid and caustic soda
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 14C
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River
- Weight at study initiation: 83-187 g
Administration / exposure
- Type of coverage:
- other: porous lids
- Vehicle:
- water
- Duration of exposure:
- once, for 72 hours
- Doses:
- 6.68 mg/kg bw (0.1 mL)
- No. of animals per group:
- 3
- Control animals:
- no
- Details on study design:
- On the day of the study the hair on the rats' back will be clipped with and Oster clipper. The area where the compound will be applied will be checked and only skin free from irritated tissue will be used.
The rats will be food-fasted overnight. The following morning the substance will be applied to the rats' backs. The rats will be dosed with 0.1 mL within two glass cells fitted with porous lids (10 cm2 total area).
The CO2 will be collected at 8-hour intervals and the urine and faeces will be collected for 24-hour intervals for the 72-hour test period.
Results and discussion
- Absorption in different matrices:
- When the substance was dosed cutaneously, most of the 14C was recovered at the test site. 94.6% of the 96.8% 14C recovered was on the skin, indicating very little absorption of the compound. Less than 0.1% of the dosed radioactivity was found in the tissues, carcass, urine and faeces. This percentage is so small that it may represent either the test compound or radiochemical impurities present in the dosing preparation.
The recovery was excellent with 96.8% of the dosed 14C accounted for.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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