Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 603-373-3 | CAS number: 129909-90-6
Clinical signs of toxicity:
No test material related clinical signs of toxicity were observed.
Bodyweight and bodyweight gain:
No test material related effects were observed.
Haematology & clinical chemistry:
Sacrifice and Gross Pathology:
No gross lesions observed at necropsy.
MKH 3582 was administeredviathe dermal route to Fischer F344 rats subjected to repeated dermal application under semi-occlusive conditions for 21 days on a 5 day/week basis during weeks 1 and 2 and daily from day 14 to 21. The exposure period was 6 hours/day. Test material doses of 0, 200, 500 and 1000 mg/kg/day were applied to 10 rats/sex/group.
The treatment produced no significant clinical signs, no effect on mean body weights or food consumption. No signs of irritation occurred at the application site. No ocular changes were seen and no effect on haematological parameters. Organ weights did not reveal any treatment related effects. Macroscopic post mortem examination did not indicate any treatment related changes.
Based on the results of this study, the NOAEL was 1000 mg/kg/day (the maximum recommended dose, in accordance with current guidelines). No evidence of toxicity was observed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again