Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 603-373-3 | CAS number: 129909-90-6
Clinical signs of toxicity:
Few clinical signs were observed and included increased lacrimation, nasal/oral staining and an unkempt appearance.
All animals survived to the scheduled necropsy
Bodyweight and bodyweight gain:
No test material related changes were observed
Sacrifice and Gross Pathology:
No gross lesions attributed to the test material were observed
Table 7.2.2: Aerodynamic particle size distribution
A group of 6 male and 6 female SD rats were exposed nose only for a single 4 hour period to MKH 3586 (as a respirable dust) at a target concentration of 2 mg/L. Test atmospheres were analysed for particulate concentration and MKH 3586. The particle size distribution of the test atmosphere was analysed hourly during the exposure period. Following exposure, the animals were retained without treatment for 14 days. Clinical observations and bodyweights were recorded throughout the study and at the end of the scheduled period the animals were killed and subjected to a gross examination post mortem.
The achieved test atmospheres had the following characteristics: Achieved concentration: 2.242 mg/L, MMAD ranged from 3.46 – 4.28 um, GSD ranged from 1.86 – 2.19.
There were no deaths, with clinical signs of toxicity limit to signs of respiratory irritation (increased lacrimation, nasal/oral staining) and an unkempt appearance. There were no test material related macroscopic findings observed at necropsy.
Nose only exposure to a particulate concentration of 2.242 mg MKH 3586/L resulted in no deaths and no adverse effects. It is concluded that the LD50 exceeds 2.242 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again