Registration Dossier

Administrative data

Description of key information

7.2.1 Acute toxicity: oral: 
KS -rat. Zorbas, 1994. KL.1. LD50 M/F: 1300 / 1015 mg/kg;
SS - Sturdivant, 1999. KL.2. LD50: 5000 mg/kg (3500 mg MKH 3586/kg)
7.2.2 Acute toxicity: inhalation:
KS - rat. Warren & Berry, 1995. KL.1. >LC50 2242 mg/m3
7.2.3 Acute toxicity: dermal:
KS - rat. Zorbas, 1994. KL.1. LD50 >2000 mg/kg
7.2.4 Acute toxicity: other routes
No available data

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
1 015 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
2 242 mg/m³

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

The acute toxicity data for amicarbazone has low toxicity via the oral (M/F 1300 / 1015 mg/kg), inhalation (>2242 mg/m3) and dermal (>2000 mg/kg) routes of exposure. Clinical signs of toxicity were most prominent following oral exposure and included decreased activity, convulsions and animals jumping when touched. These signs were accompanied by reddened lungs and blackened zones in the glandular stomach mucosa in all animals which did not survive to the scheduled necropsy. No gross abnormalities were observed in animals dosedviathe dermal or inhalatory route.

Justification for classification or non-classification

Acute oral toxicity:The test material should be classified as ‘Acute Tox 4’ and the hazard statement ‘H302; Harmful if swallowed’ should be applied according to the harmonised classification in Regulation 1272/2008.

 

Acute toxicity inhalation:The test material should be classified as ‘Acute Tox 4’ and the hazard statement ‘H332: Harmful if inhaled' should be applied according to the harmonised classification in Regulation 1272/2008.

 

Acute toxicity dermal:The test material should be classified as ‘Acute Tox 4’ and the hazard statement ‘H312: Harmful in contact with skin’ should be applied according to the harmonised classification in Regulation 1272/2008.