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EC number: 500-537-5 | CAS number: 161075-00-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Henry's Law constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- Henry's law constant
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Study period:
- not applicable
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- other: Guidance on Information Requirements and Chemical Safety Assessment_Chapter R.7a: Endpoint specific guidance_version 3
- Qualifier:
- according to guideline
- Guideline:
- other: Guidance on Information Requirements and Chemical Safety Assessment_ Chapter R.16: Environmental Exposure Estimation_ Version 2.1
- Principles of method if other than guideline:
- Henry's Law constant is calculated from the ratio of the vapour pressure to the water solubility.
- H:
- 13 792 979 Pa m³/mol
- Temp.:
- 20 °C
- Remarks on result:
- other: calculated
- H:
- 20 660 426 Pa m³/mol
- Temp.:
- 20 °C
- Remarks on result:
- other: calculated
- Conclusions:
- The Henry's Law constant of GALDEN LMW at 20°C, calculated for the two GALDEN LMW grades is:
HLC = 20660426Pa m3/mol
HLC =13792979Pa m3/mol - Executive summary:
The HENRY Law constant of GALDEN LMW has been calculated according to the following equation:
HLC = (VP x molW) / Water Solubility
(Reference: Guidance on Information Requirements and Chemical Safety Assessment_ Chapter R.16: Environmental Exposure Estimation_ Version 2.1_Equation R.16-4)
The Henry's Law constant of GALDEN LMW, calculated for the two GALDEN LMW grades is resulted to be:
HLC = 20660426 Pa m3/mol (at 20°C)
HLC =13792979 Pa m3/mol (at 20°C)
The typical mean values as used as calculation parameters.
The results indicate that both the GALDEN LMW grades have the same magnitude of volatilization.
Reference
Description of key information
The HENRY Law constant of GALDEN LMW has been calculated according to the equation: HLC = (VP x molW) / Water Solubility.
The results indicate that GALDEN LMW has a very high tendency to distribute from water to the air. Volatilisation of GALDEN LMW from water is expected to be extremely rapid.
Key value for chemical safety assessment
- Henry's law constant (H) (in Pa m³/mol):
- 17 226 702.5
- at the temperature of:
- 20 °C
Additional information
Galden is a multi-constituent substance consisting of low molecular weight perfluoropolyethers (PFPE). Two grades of Galden LMW are manufactured (Galden HT55 and HT70), which contain the same perfluorinated constituents and differ only in the relative concentration of the constituents.
The Henry's Law constant of GALDEN LMW, calculated according to the equation: HLC = (VP x molW) / WS for the two GALDEN LMW grades, results to be:
HLC (HT 55) = 20660426 Pa m3/mol (at 20°C)
HLC (HT 70) =13792979 Pa m3/mol (at 20°C)
(Reference: Guidance on Information Requirements and Chemical Safety Assessment_ Chapter R.16: Environmental Exposure Estimation_ Version 2.1_Equation R.16-4)
The values indicates that GALDEN LMW has a very high tendency to distribute from water to the gas phase.
As reported in Guidance on Information Requirements and Chemical Safety Assessment_Chapter R.7a,substances with HLC values around 100 Pa·m3/mol, will have a rapid volatilisationfrom water. Basing on the calculated Henry’s Law constant value, volatilization of GALDEN LMW from water is expected to be extremely rapid.
The calculated average value HLC =17226702,5 Pa m3/mol (at 20°C) for Galden HT70 and GALDEN HT55 has been set as key value for risk assessment purpose.
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