Registration Dossier
Registration Dossier
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EC number: 245-528-4 | CAS number: 23255-99-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
Materials and methods
- Principles of method if other than guideline:
- Method not published
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium [[1-(phenylmethyl)-1H-indazol-3-yl]oxy]acetate
- EC Number:
- 245-528-4
- EC Name:
- Sodium [[1-(phenylmethyl)-1H-indazol-3-yl]oxy]acetate
- Cas Number:
- 23255-99-4
- Molecular formula:
- C16H14N2O3.Na
- IUPAC Name:
- sodium [(1-benzyl-1H-indazol-3-yl)oxy]acetate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation:
- Weight at study initiation: 150-200 grams
- Fasting period before study: 3 hours
- Housing: climate controlled room
- Diet : ad libitum
- Water : ad libitum
- Acclimation period:
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- 8-26.5 % suspension of test article i 0.1% CMC
- Doses:
- 1000, 2000, 3980 and 7940 mg/kg
- No. of animals per sex per dose:
- 4 groups of 10 male rats
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 610 mg/kg bw
- Clinical signs:
- other: Lungs, thorax or respiration: dyspnea Behavioral: ataxia
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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