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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted by GLP accredited lab according to OECD method n. 401

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report date:
1988

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Test type:
standard acute method

Test material

Constituent 1
Reference substance name:
Tin(II) bis(methanesulfonate)
EC Number:
401-640-7
EC Name:
Tin(II) bis(methanesulfonate)
IUPAC Name:
tin(II) bis(methanesulfonate)
Constituent 2
Reference substance name:
53408-94-9
EC Number:
610-996-4
Cas Number:
53408-94-9
IUPAC Name:
53408-94-9

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
No. of animals per sex per dose:
5
Statistics:
slope of log10(dose) = 11.3 for combined sexes with standard error deviation = 3.24

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 621 mg/kg bw
Based on:
test mat.
95% CL:
> 1 272 - < 2 087

Any other information on results incl. tables

In the dose ranging study all animals died at 5000 and 2500 mg/kg and one female at 1250 mg/kg died within 3 days of dosing.

Common abnormalities noted at necropsy were darkening and thickening of the stomach glandular mucosa and a pink colouration of the mucosa. There were several incidences of occular damage and discoloration of the undersurface of the lobes of the liver.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
harmful is swallowed