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EC number: 265-111-0 | CAS number: 64742-11-6 A complex combination of hydrocarbons obtained as the extract from a solvent extraction process. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C20 through C50. This stream is likely to contain 5 wt. % or more of 4- to 6-membered condensed ring aromatic hydrocarbons.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
NOAEL for heavy paraffinic distillate aromatic extract could not be identified in a 90-day oral study (equivalent to OECD 408) and is less than 125 mg/kg/day when administered orally to male rats. Systemic toxicity was observed in a 90-day dermal study (equivalent to OECD 411) in rats exposed to heavy paraffinic DAE (CAS number 64742-04-7). A NOAEL could not be established since toxicity was observed at all dosing levels, including the lowest dose tested. The authors considered the NOAEL for dermal exposure to be less than 30 mg/kg/day. In a 28-day dermal study (equivalent to OECD 410), no signs of systemic toxicity were observed in rabbits even at the high dose, 1000 mg/kg/day.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LOAEL
- 125 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LOAEL
- 30 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Additional information
Heavy paraffinic DAE (CAS number 64742-04-7) was tested dermally and orally in a 13-week (subchronic) toxicity study in rats (Mobil, 1990). Light paraffinic DAE (CAS number 64742-05-8) also was tested dermally in a 28-day (subacute) toxicity study in rabbits (API, 1986b). There are no repeated dose toxicity studies identified for exposure via inhalation.
Repeated Dose Toxicity - Oral
In a subchronic oral toxicity study, heavy paraffinic distillate aromatic extract was administered to 10 male Sprague-Dawley rats/dose at dose levels 0, 125, or 500 mg/kg bw/day 5 days a week for 13 weeks. Four of ten rats in the 500 mg/kg/day group were sacrificed prior to scheduled termination. All animals in the 125 mg/kg/day survived to date of sacrifice. No details on clinical signs were provided. Body weight was significantly reduced in the 500-mg/kg/day group. A significant decrease (p<0.05) in red blood cell (RBC) parameters (including RBC count, haemoglobin, and haematocrit) and platelet count occurred in males dosed orally at 500 mg/kg/day. Males orally dosed at 125 mg/kg/day showed a significant decrease in RBC parameters; platelet counts were slightly decreased in these rats but did not achieve statistical significance. There were no significant differences in the RBC morphology or WBC differential data. The only statistically significant difference between the serum data from control and orally dosed rats was observed for SDH (0 mg/kg/day = 5±2 IU/l, 150 mg/kg/day = 8±2 IU/l, 500 mg/kg/day = 9±7 IU/l). Treatment-related dose-dependent changes in relative organ weights included increased liver weight in both groups, decreased prostate weight in both groups, decreased seminal vesicle weight in the high-dose group, and decreased thymus weight in both groups. Focal areas of red discoloration and or generalized reddening were also observed in the brain, spinal cord, stomach and testes of many of the rats dosed orally at 500 mg/kg/day. Treatment-related histopathology was generally dose-dependent and occurred in the following tissues: adrenals, bone marrow, liver, stomach and thymus. Atrophy occurred in the male sex organs (testes, seminal vesicle, and prostate). Sperm evaluations showed a significant increase in the frequency of sperm with abnormal heads in the rats dosed orally at 500 mg/kg/day (1.9% in controls and 3.2% in treated rats).
A NOAEL for heavy paraffinic distillate aromatic extract could not be identified and is less than 125 mg/kg/day when administered orally.
Repeated Dose Toxicity - Dermal
Heavy paraffinic DAE (CAS number 64742-04-7) was tested in a 13-week dermal toxicity study in rats, at similar and lower doses than those tested in the 28-day test (Mobil, 1990). By contrast to the subacute test, lethality and a number of systemic effects were caused by exposure, while lesser skin irritation was observed. Histopathological changes were most prominent (and generally dose related) in the liver, thymus, adrenals, kidneys, lymph nodes, stomach, bone marrow and treated skin.
A NOAEL could be established for DAE for dermal exposures since toxicity was observed at all dosing levels, including the lowest dose tested. The authors considered the NOAEL for dermal exposure to be less than 30 mg/kg/day.
Light paraffinic DAE (CAS number 64742-05-8) was tested by repeated dermal exposure for 28 days in rabbits at doses up to 1000 mg/kg/day (API, 1986b). The tested material was moderately irritating and caused proliferative changes to skin. No significant effects on body weight gain, haematology or gross and microscopic pathology were observed, and no significant systemic effects were noted.
Justification for selection of repeated dose toxicity via oral route - systemic effects endpoint:
only one study available
Repeated dose toxicity: via oral route - systemic effects (target organ) cardiovascular / hematological: bone marrow; cardiovascular / hematological: thymus; digestive: liver; digestive: stomach; glandular: adrenal gland; urogenital: prostate; urogenital: seminal vesicle; urogenital: testes
Repeated dose toxicity: dermal - systemic effects (target organ) cardiovascular / hematological: bone marrow; cardiovascular / hematological: lymph nodes; cardiovascular / hematological: thymus; digestive: liver; glandular: adrenal gland; urogenital: kidneys; other: skin
Justification for classification or non-classification
Based on dermal subchronic repeat dose toxicity results and a NOAEL of < 30 mg/kg/day, distillate aromatic extracts are classified under the EU CLP Regulation (EC No. 1272/2008) as STOT RE1 (H372).
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