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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Dermal application of radio labelled distillate aromatic extract in the pregnant rat resulted in low levels of uptake of key constituents in maternal tissues.  Very low levels of radioactivity were detected in the foetus.

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential

Additional information

In a bioavailability toxicokinetics study in pregnant rats, 1000 mg/kg of radiolabelled 318 isthmus furfural extract (a distillate aromatic extract) was dermally applied on gestation days 10, 11, and 12 (Mobil 1989). Maternal tissues, blood, placentas, uteri, embryos, and yolk sacs were collected and analyzed for radioactivity on gestation day 13 following sacrifice. Urine, faeces, and cage wash was collected every 24 hours and also analyzed for radioactivity.

Dermal absorption of 14C-carbazole occurred more extensively than did 3H-benzo(a)pyrene over a 72 hour period. About 19.9% and 4.1% of the total applied of 14C-carbazole and 3H-benzo(a)pyrene, respectively, was dermally absorbed. Of the total absorbed dose of 14-C-carbazole, 2.1% was found in the maternal tissues and less than 0.01% was detected in the embryo. Of the total absorbed dose of 3H-benzo(a)pyrene 1.8% was detected in the maternal tissue and less than 0.01% was found in the embryo. 17.7% of 14C-carbazole was excreted in the urine and faeces over 72 hours. 2.3% of 3Hbenzo(a)pyrene was excreted in the urine and faeces over 72 hours.

Based on the bioavailability results, neither of the radiolabelled components of 318 isthmus furfural extract were found to selectively accumulate in the embryo.

Mutagenicity and carcinogenicity of a series of 39 petroleum oils, including several DAEs, were correlated with the content of 3-7 ring PACs. Further, the steady-state dermal penetration of PAC in long-term testing was also determined predominantly by PAC concentration. Although aromaticity and viscosity had a minimal effect on dermal penetration, neither was an important determinant of the carcinogenic potency.


Substances in this category are UVCBs; hence it is not possible to apply standard methodology for assessing absorption, distribution and metabolism. Relevant data for use in risk assessment are available for constituent compounds.