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Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information

Genetic toxicity and Chromosome aberration by 4-(2,6,6-trimethylcyclohex-1-ene-1-yl)-but-3-ene-2-one gives negative result.

Link to relevant study records
Reference
Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from ACToR database
GLP compliance:
not specified
Type of assay:
bacterial gene mutation assay
Species / strain / cell type:
S. typhimurium TA 100
Additional strain / cell type characteristics:
not specified
Metabolic activation:
with
Metabolic activation system:
HAMSTER, LIVER, S-9, AROCLOR 1254 (10%)
Test concentrations with justification for top dose:
3.3-180 UG/PLATE
Details on test system and experimental conditions:
Test condition: PREINCUBATION
Species / strain:
S. typhimurium TA 100
Metabolic activation:
with
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
no cytotoxicity
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.
Conclusions:
Interpretation of results (migrated information):
negative

Genetic toxicity with Metabolic Activation of HAMSTER, LIVER, S-9, AROCLOR 1254 (10%) by bacterial gene mutation assay to TA98 AMES SALMONELLA TYPHIMURIUM was examined to be NEGATIVE.
Executive summary:

Genetic toxicity with Metabolic Activation of HAMSTER, LIVER, S-9, AROCLOR 1254 (10%) by bacterial gene mutation assay to TA98 AMES SALMONELLA TYPHIMURIUM was examined to be NEGATIVE.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Additional information

Additional information from genetic toxicity in vitro:

Genetic toxicity ames test :-

Genetic toxicity with Metabolic Activation of HAMSTER, LIVER, S-9, AROCLOR 1254 (10%) by bacterial gene mutation assay to TA98 AMES SALMONELLA TYPHIMURIUM examined as NEGATIVE.

Chromosome aberration test:-

Based on the prediction for in-vitro mammalian chromosome aberration test on Chinese hamster Lung (CHL) without S9 metabolic activation it was estimated that 4-(2,6,6-trimethylcyclohex-1-ene-1-yl)-but-3-ene-2-one does not exhibit positive chromosomal effect.

Justification for selection of genetic toxicity endpoint

Genetic toxicity with Metabolic Activation of HAMSTER, LIVER, S-9, AROCLOR 1254 (10%) by bacterial gene mutation assay to TA98 AMES SALMONELLA TYPHIMURIUM was examined to be NEGATIVE.

Justification for classification or non-classification