Registration Dossier
Registration Dossier
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EC number: 603-491-5 | CAS number: 131513-00-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992-03-04 to 1992-03-25
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EEC Directive 84/449, 1984
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- testing lab.
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4-{[(4-benzoylphenoxy)carbonyl]oxy}butyl prop-2-enoate
- EC Number:
- 603-491-5
- Cas Number:
- 131513-00-3
- Molecular formula:
- C21H20O6
- IUPAC Name:
- 4-{[(4-benzoylphenoxy)carbonyl]oxy}butyl prop-2-enoate
- Test material form:
- other: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH, Biberach, Germany
- Age at study initiation: young adult animals
- Weight at study initiation: 150 g- 300 g
- Housing: singel housing in stainless steel wire mesh cages, type DK-III (Becker & Co., Castrop-Rauxel, Germany)
- Diet: Kliba Labordiaet 343, Klingentalmuehle AG, CH-4303 Kaiseraugst, Switzerland
- Water: tap water ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- Acclimatization period: at least 1 week
Fasting period: at least 16 hours before administration; water was available ad libitum
Form of administration: emulsion
Amounts administered: 2200 mg/kg - concentration: 44.000 g/100 mL - administration volume: 5.00 mL/kg - Doses:
- 2200 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- Duration of observation period following administration: 14 days
A check was made twice each working day and once on Saturdays, Sundays and public holidays for general observations and for any dead or moribund animal.
Body weight determination: shortly before application and then weekly and at the end of the study (before fasting period).
Signs and symptoms were recorded several times on the day of administration, at least once each working day for the individual animals.
Necropsy was done at the last day of the observation period (withdrawal of food at least 16 h before killing with CO2; then necrospy with gross-pathological examination.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- other: none
- Gross pathology:
- nothing abnormal detected
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
