2-dodecylhexadecan-1-ol

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

GLP compliance:

yes (incl. QA statement)

Reference substance (positive control):

yes

Remarks:

potassium dichromate (once per month, test conducted April 7 to 8, 2010)

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Validity criteria fulfilled:

yes

Conclusions:

2-Dodecylhexadecan-1-ol is not toxic to daphnia within the range of water solublity.The LC50 is > 100 mg/l (nominal).

Executive summary:

According to data of two structurally similar substances (2-hexyldecan-1-ol (C16) and mixture of 2 -octyldodecan-1-ol and 2 -hexyl-1-tetradecanol (C20)) which show no acute toxicity to daphnia up to the limit of water solubility no toxicity to invertebrates is expected for 2-Dodecylhexadecan-1-ol up to the limit of water solubility.

Description of key information

Experimental data on two representatives of the category (C16 and C32/36) show no acute toxicity to fish up to the limit of water solubility. These results were cross-read to 2-dodecylhexadecan-1-ol.

Additional information

2-Dodecylhexadecan-1-ol is a member of the Guerbet Alcohols, which comprises a range of branched long chain alcohols C12-32. It is also structurally related to the substances of the OECD SIDS Long Chain Alcohols (LCA) categories, comprising a range of straight and branched long chain alcohols C6-22. As defined in the ‘Read Across Justification Document’ in section 13, data provided for these categories is representative of 2-dodecylhexadecan-1-ol and suitable for assessment purposes. Experimental data for the Guerbet and LCA categories has been evaluated and trends in the environmental fate of long chain alcohols was used to extrapolate to the C28 alcohol, 2-dodecylhexadecan-1-ol for ecotoxicological endpoints.

No data on short-term toxicity of 2-dodecylhexadecan-1-ol to invertebrates were available. However, there are data on acute toxicity to daphnia for three representatives of the Guerbet alcohol category; specifically 2-hexyldecan-1-ol, 2-butyloctan-1-ol, and a mixture of 2-octyldodecan-1-ol and 2-hexyltetradecan-1-ol.

The C12 Guerbet alcohol 2-butyloctan-1-ol show acute toxicity to daphnia in contrast to the higher alcohols 2-hexyldecan-1-ol (C16) and mixture of 2 -octyldodecan-1-ol and 2 -hexyl-1-tetradecanol (C20) which show no acute toxicity to daphnia up to the limit of water solubility. These effects can be a consequence of decreasing water solubility with increasing chain length. Thus no aquatic toxicity is considered for the Guerbet alcohols with chain lengths >= C16 with an extremely low water solubility.