Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Details of toxic effects not reported other than lethal dose value.

Data source

Reference
Reference Type:
publication
Title:
Evaluation of Delayed Neurotoxicity and Dose-Response Relationships of Phosphate Esters in the Adult Hen
Author:
Johannsen, F. R.; Wright, P. L.; Gordon, D. E.; Levinskas, G. J.; Radue, R. W. and Graham P. R.
Year:
1977
Bibliographic source:
TOXICOLOGY AND APPLIED PHARMACOLOGY Vol. 41, Pg. 291-304 (1977)

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Undiluted test material was applied (dorsal) to rabbits to determine the LD50.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): o-Xenyl diphenyl phosphate
- Composition of test material, percentage of components: no quantitative information is available on o-xenyl diphenyl phosphate

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 hours
Doses:
Maximum dosage: 7.9 g/kg
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 7.9 other: g/kg
Based on:
not specified
Remarks on result:
other: rabbit

Any other information on results incl. tables

Details of toxic effects not reported other than lethal dose value.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 (rabbit) >7.9 g/kg