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Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: GLP screening study
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1998
Report date:
1998

Materials and methods

Principles of method if other than guideline:
Mouse local lymph node assay (LLNA)
GLP compliance:
yes
Type of study:
mouse local lymph node assay (LLNA)

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4-dichloro-5-isopropoxyaniline
EC Number:
255-258-9
EC Name:
2,4-dichloro-5-isopropoxyaniline
Cas Number:
41200-96-8
Molecular formula:
C9H11Cl2NO
IUPAC Name:
2,4-dichloro-5-isopropoxyaniline
Details on test material:
- Name of test material (as cited in study report): 2,4-dichloro 5-isopropoxy aniline (DIA)
- Storage condition of test material: stored in the dark at room temperature in air-tight containers

In vivo test system

Test animals

Species:
mouse

Results and discussion

Any other information on results incl. tables

No indication of the test results provided

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Under the test conditions, 2,4-Dichloro-5-isopropoxyaniline is not a skin sensitiser in the mouse local lymph node assay.
Executive summary:

In a mouse local lymph node assay performed in compliance with the GLP, 2,4-Dichloro-5-isopropoxyaniline ( named as 2,4-dichloro 5-isopropoxy aniline (DIA))has a relatively low skin sensitisation potential. It is therefore not classified for skin sensitisation according to the Regulation (EC) 1272/2008 and the Directive 67/548/EEC.

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