Registration Dossier
Registration Dossier
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EC number: 255-258-9 | CAS number: 41200-96-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP screening study
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
- Principles of method if other than guideline:
- 3 single oral doses of test material were administered to three groups of rats.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,4-dichloro-5-isopropoxyaniline
- EC Number:
- 255-258-9
- EC Name:
- 2,4-dichloro-5-isopropoxyaniline
- Cas Number:
- 41200-96-8
- Molecular formula:
- C9H11Cl2NO
- IUPAC Name:
- 2,4-dichloro-5-(propan-2-yloxy)aniline
- Details on test material:
- - Name of test material (as cited in study report): 2,4-dichloro 5-isopropoxy aniline (DIA)
- Storage condition of test material: stored in the dark at room temperature in air-tight containers
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: unspecified
- Doses:
- 25; 200 and 2000 mg/kg bw
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the test conditions, 2,4-Dichloro-5-isopropoxyaniline is not classified for acute oral toxicity in the rat according to the criteria of the Regulation (EC) 1272/2008 and the Directive 67/548/EEC as the LD 50 is higher than 2000 mg/kg bw.
- Executive summary:
In an acute oral toxicity screening study, performed in compliance with the GLP, three groups of rats were given a single oral dose of undiluted 2,4-Dichloro-5-isopropoxyaniline (named as 2,4-dichloro 5-isopropoxy aniline (DIA) in the study report) at doses of 25; 200 or 2000 mg/kg bw.
Oral LD50rat > 2000 mg/kg bw
Under the test conditions, 2,4-Dichloro-5-isopropoxyaniline is not classified for acute oral toxicity in the rat according to the criteria of the Regulation (EC) 1272/2008 and the Directive 67/548/EEC as the LD 50 is higher than 2000 mg/kg bw.
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