Ethyl 2,3-epoxy-3-phenylbutyrate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

No data

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Insufficient experimental details given in incomplete study report.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Principles of method if other than guideline:

Method not specified.

GLP compliance:

no

Remarks:

Study predates adoption of GLP

Test type:

other: No data

Test material

Test material information

Constituent 1

Reference substance name:

Ethyl 2,3-epoxy-3-phenylbutyrate

EC Number:

201-061-8

EC Name:

Ethyl 2,3-epoxy-3-phenylbutyrate

Cas Number:

77-83-8

Molecular formula:

C₁₂H₁₄O₃

IUPAC Name:

ethyl 3-methyl-3-phenyloxirane-2-carboxylate

Details on test material:

- Name of test material (as cited in study report): Aldehyde C16 EOA 76-7
- Substance type: No data
- Physical state: No data
- Analytical purity: No data
- Impurities (identity and concentrations): No data
- Composition of test material, percentage of components: No data
- Isomers composition: No data
- Purity test date: No data
- Lot/batch No.: No data
- Expiration date of the lot/batch: No data
- Stability under test conditions: No data
- Storage condition of test material: No data

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: No data
- Fasting period before study: No data
- Housing: No data
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: No data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

not specified

Details on oral exposure:

VEHICLE
- Concentration in vehicle: No data
- Amount of vehicle (if gavage): No data
- Justification for choice of vehicle: No data
- Lot/batch no. (if required): No data
- Purity: No data

MAXIMUM DOSE VOLUME APPLIED: Up to 5 g/kg body weight

DOSAGE PREPARATION (if unusual): No data

CLASS METHOD (if applicable)
- No data

Doses:

Up to 5 g/kg body weight

No. of animals per sex per dose:

10 animals used, details unclear.

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observation daily on days 1-14
- Necropsy of survivors performed: No data
- Other examinations performed: clinical signs, body weight, organ weights, histopathology, other: No data

Statistics:

No data

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

0/10

Clinical signs:

other: No data

Gross pathology:

No data

Other findings:

- Organ weights: No data
- Histopathology: No data
- Potential target organs: No data

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information

Conclusions:

The acute oral LD₅₀ of the test material ethyl 2,3-epoxy-3-phenylbutyrate was determined as >5000 mg/kg bw.