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EC number: 289-296-2 | CAS number: 87061-04-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source
- Justification for type of information:
- Derived using calculation method software which has been validated for organic substances.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Derived using calculation method software which has been validated for organic substances.
- GLP compliance:
- no
- Test type:
- not specified
- Water media type:
- not specified
- Total exposure duration:
- 96 h
- Hardness:
- not available
- Test temperature:
- not available
- pH:
- not available
- Dissolved oxygen:
- not available
- Salinity:
- not available
- Conductivity:
- not available
- Nominal and measured concentrations:
- not available
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Remarks:
- freshwater
- Effect conc.:
- 8.508 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Remarks:
- saltwater
- Effect conc.:
- 10.808 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- mortality (fish)
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The estimated EC50 for freshwater fish was 8.508 mg/L.
- Executive summary:
USA's EPA ECOSAR software is used to assess the toxicity on fish of the test item.
Measured values of the log Kow and the water solubility are used.
EC96h fish = 8.508 mg/ L
EC96h fish (saltwater) = 10.808 mg/ L
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: "Bioaccumulation test of chemical substances in fish and shellfish" described in "Kanpogyou, No.5", "Yakuhatsu, No.615" and "49 Kikyoku, No.392
- GLP compliance:
- yes
- Analytical monitoring:
- not specified
- Details on sampling:
- (1) Test water;
The test substance in the test water was analyzed twice every week, 16 times in total for both concentration 1 and 2 area during
exposure period using one sample each time.
(2) Test fish;
The test substance in the test fish was analyzed 2,4,6 and 8 week, 4 times in total, after the initiation of exposure for both
concentration 1 and 2, using two fish samples each time. - Vehicle:
- yes
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST FISH;
Common name: Common carp
Species: Carp (Cyprinus carpio)
Source: Kitamura fish farm (Yatsushiro-city, Kumamoto)
Lot. No.: TFC840717
Treatment: Sample fish were treated by placing them in a tetracycline hydrochloride solution (10 mg/L) under static water
conditions during 24-hours.
Acclimatization period: 14 days, 25oC.
Standard size of fish used in the study*:
Mean body weight; 22.4 g
Mean length; 9.7 cm
Mean content of lipid; 4.2%
* Measured value of representative sample from same acclimatization lot. - Test type:
- flow-through
- Water media type:
- freshwater
- Total exposure duration:
- 8 wk
- Hardness:
- No description
- Test temperature:
- Breeding temperature: 25 ± 2°C
- pH:
- No description
- Dissolved oxygen:
- Dissolved oxygen concentration in test aquarium:
Concentration 1 area; 5.7 – 7.3 mg/L
Concentration 2 area; 6.2 – 7.5 mg/L - Salinity:
- No description
- Nominal and measured concentrations:
- The nominal test substance concentrations and the mean measured test substance concentrations of test water were shown in
Table.2. - Details on test conditions:
- TEST SYSTEM;
(1) Equipment: Environmental control equipment with a flow-through water system
(2) Tank: 100 L glass aquarium
(3) Flow rate: 582 L/day
(stock solution : dilution water = 4 mL/minute : 400 mL/minute)
(4) Number of test fish used: 20 fish each breeding aquarium ( at the initiation of exposure)
(5) Exposure period: 8 weeks
(6) Exposure temperature: 25 ± 2°C
(7) Feeding: An amount of corresponding to about 2% of the test fish bodyweight was fed twice daily in halves.
RATIONAL OF THE TEST MATERIAL CONCENTRATION FOR DEFINITIVE TEST;
Based on the preliminary test result for 48-hr LC50, the test substance concentrations for definitive test were determined as
follows;
Concentration 1 area: 0.5 mg/L
Concentration 2 area: 0.05 mg/L
PRELIMINARY TEST;
(1) Test method: The preliminary test was performed according to the method of “Acute Toxicity Test in Fish” described in
Factory Effluent Test Method provided in JIS K 0102 using HCO-40 as dispersing agent.
(2) Species: Killifish (Oryzia latipes)
(3) During exposure: 48 hours
(4) Test result: 48-hr LC50 of test substance; 48.5 mg/L
(5) Dilution water: well water - Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 48.5 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Results determined in a preliminary test on Species: Killifish (Oryzia latipes), according to the method of “Acute Toxicity Test in Fish” described in Factory Effluent Test Method provided in JIS K 0102 using HCO-40 as dispersing agent.
- Details on results:
- no data
- Results with reference substance (positive control):
- no data
- Conclusions:
- The 48 hour LC50 was ca 48.5 mg/L.
- Executive summary:
Information on the short term toxicity to fish was included in the "Bioaccumulation test of chemical substances in fish and shellfish" described in "Kanpogyou, No.5", "Yakuhatsu, No.615" and "49 Kikyoku, No.392.
Under the conditions of the study, the 48 hour LC50 was determined to be ca 48.5 mg/L to Cyprinus carpio.
Referenceopen allclose all
Description of key information
"Bioaccumulation test of chemical substances in fish and shellfish" described in "Kanpogyou, No.5", "Yakuhatsu, No.615" and "49 Kikyoku, No.392
The 48 hour LC50 was ca 48.5 mg/L
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 48.5 mg/L
Additional information
The information that has been taken from a bioaccumulation study which was conducted with the substance on the freshwater fish Cyprinus carpio. The study was awarded a reliability score of 2 in accordance with the criteria set forth by Klimisch et al. (1997).
Under the conditions of the study the 48 hour LC50 was determined to be ca 48.5 mg/L
The experimental result is taken forward as the key data.
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