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EC number: 228-085-1 | CAS number: 6117-80-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Non-GLP study that meets key elements of current OECD 402 guideline with some notable restrictions (8 day observation instead of 14, skin surface area <10%). Suitable for use in classification if dermal absorption rate and oral toxicity taken into account.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- 8-day observation period instead of 14; skin surface area <10%, top dose was only 200 mg/kg
- Principles of method if other than guideline:
- Method: other: BASF-Test
- GLP compliance:
- no
- Test type:
- other: Acute dermal toxicity
Test material
- Reference substance name:
- But-2-ene-1,4-diol
- EC Number:
- 203-787-0
- EC Name:
- But-2-ene-1,4-diol
- Cas Number:
- 110-64-5
- Molecular formula:
- C4H8O2
- IUPAC Name:
- 2-Butene-1,4-diol
- Reference substance name:
- (Z)-2-butene-1,4-diol
- EC Number:
- 228-085-1
- EC Name:
- (Z)-2-butene-1,4-diol
- Cas Number:
- 6117-80-2
- Molecular formula:
- C4H8O2
- IUPAC Name:
- but-2-ene-1,4-diol
- Details on test material:
- - Name of test material (as cited in study report): Buten-2-diol-1,4 (cis)
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 50 cm²
REMOVAL OF TEST SUBSTANCE
- Washing : After the exposure time the skin was washed with detergent and water
- Duration of exposure:
- 24 hours
- Doses:
- 200 mg/kg bw
- No. of animals per sex per dose:
- 5 males, 5 females
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: No abnormal clinical signs were observed.
- Gross pathology:
- No abnormalities were noted at necropsy.
Any other information on results incl. tables
| Dose | Sex | 1 h | 24 h | 48 h | 8 days |
| 200 mg/kg | male | 0/5 | 0/5 | 0/5 | 0/5 |
| 200 mg/kg | female | 0/5 | 0/5 | 0/5 | 0/5 |
Applicant's summary and conclusion
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