(Z)-2-butene-1,4-diol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Study is comparable with the inhalation hazard test described in the Annex of OECD Guideline 403 (adopted 1981) with restrictions (partly limited documentation; nominal atmosphere concentration; vapour only). Not suitable for classification if aerosol exposure likely.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1959

Report date:

1959

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Version / remarks:

Inhalation hazard test (Annex)

Deviations:

yes

Remarks:

nominal air concentration, vapour only

Principles of method if other than guideline:

Method: other: BASF-Test (Inhalation Risk Test)

GLP compliance:

no

Test type:

other: Inhalation Risk Test

Test material

Test material information

Constituent 1

Reference substance name:

But-2-ene-1,4-diol

EC Number:

203-787-0

EC Name:

But-2-ene-1,4-diol

Cas Number:

110-64-5

Molecular formula:

C4H8O2

IUPAC Name:

2-Butene-1,4-diol

Constituent 2

Reference substance name:

(Z)-2-butene-1,4-diol

EC Number:

228-085-1

EC Name:

(Z)-2-butene-1,4-diol

Cas Number:

6117-80-2

Molecular formula:

C4H8O2

IUPAC Name:

but-2-ene-1,4-diol

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

other: conditioned air

Details on inhalation exposure:

Rats exposed for 2 h and 8 h, respectively, to a vapour saturated atmosphere.

Vapour was generated by bubbling 200 l/h dry air (no CO2) through the liquid substance column (volume ca. 50 ml) of about 5 cm above a fritted glass disc in a glass cylinder. The glass cylinder was heated in a water bath. The air pressure was 730 - 740 mm Hg . Temperature in the exposure chamber was 20°C.

The saturated vapour pressure was calculated to be approximately 0.024 mg/L at 20°C.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

0.024 mg/l (nominal), saturated vapour concentration at 20°C.

No. of animals per sex per dose:

3

Control animals:

not specified

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

0.024 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

8 h

Remarks on result:

other: Inhalation Hazard test

Mortality:

No mortality was observed.

Gross pathology:

No abnormal findings.