Registration Dossier
Registration Dossier
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EC number: 200-293-7 | CAS number: 56-86-0
Carcinogenicity
Administrative data
Description of key information
Read-cross from Monosodium glutamate (EC 205-538-1):
Carcinogenicity study of Monosodium L-Glutamate in Fischer 344 Rats: Non GLP, but well documented publication, study performed in agreement with OECD 451.
Key value for chemical safety assessment
Justification for classification or non-classification
Based on the information available, L-Glutamic acid is not a genotoxic carcinogen and therefore no
classification(67/548/EECandCLPregulation) as carcinogen is required.
Additional information
Monosodium glutamate, an analogue substance, administration at levels up to 5.0% in the diet (equivalent to 1982 mg/kg bw/day for males and 2311 mg/kg bw/day for females) for 104 wk was not carcinogenic for male and female Fischer 344 rats. Effects observed were increased urinary volume (males, 5% w/w), increased pH and sodium levels and reduced urinary potassium levels (males and females, 2.5% w/w and 5% w/w) , increased relative kidney weight (males and females, 5% w/w) and increased urinary bladder weight (males, 5% w/w). Due to the limited number of parameters measured it is not appropriate to derive a NOAEL for toxicity from the results of this study.
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