Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 308-733-0 | CAS number: 98219-64-8 A complex combination of hydrocarbons obtained by the treatment and distillation of raw steam-cracked naphtha. It consists predominantly of unsaturated hydrocarbons boiling in the range above approximately 180°C (356°F).
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Non human data
CAS 68475-80-9 (E000014200): Albino guinea pigs were dermally exposed to neat E000014200 at a volume of 0.5 mL for induction phases one and two and to a 1:2 v/v dilution (in mineral oil) for induction three. The test article was administered as a 1:4 v/v dilution (in mineral oil) for the challenge phase for both the induction/challenge and challenge control group animals. Following challenge there were no responses in E000014200 or vehicle control animals whilst all 10 in the positive control group had responses (UBTL, 1990e).
The components benzene, toluene, ethylbenzene, styrene, naphthalene, biphenyl and anthracene are considered not to be skin sensitisers.
Human data
The only human data identified was for benzene:
Benzene (No classification): In a study using 25 male volunteers a maximisation test with induction using 50% benzene and challenge with 20% benzene no evidence of skin sensitisation was seen (Kligman, 1966).
Migrated from Short description of key information:
Fuel Oils streams are considered not to be skin or respiratory sensitisers. Specific data for one Fuel Oils stream E000014200 (CAS 68475-80-9) indicates that it is not a skin sensitiser. The components benzene, toluene, ethylbenzene, styrene, naphthalene, biphenyl and anthracene are considered not to be skin sensitisers.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
No specific animal or human data have been found with regard to respiratory sensitisation for any components within this stream.
Migrated from Short description of key information:
No data have been found concerning respiratory sensitisation and there are no indications that components within this stream are respiratory allergens.
Justification for classification or non-classification
There are sufficient data on E000014200 (CAS 68475-80-9) and on component substances to indicate that Fuel Oils streams are not skin sensitisers. Although there are no specific data on respiratory sensitisation of Fuel Oils streams or marker components there are no indications that components within this stream are respiratory allergens. It is proposed that no classification is warranted for these end-points under Dir 1999/45/EC or Reg (EC) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
