Registration Dossier
Registration Dossier
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EC number: 208-066-4 | CAS number: 507-20-0
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: reliable literature source and QSAR
Data source
Reference
- Reference Type:
- publication
- Title:
- Hydrolysis
- Author:
- Mabey and Mill
- Year:
- 1 978
- Bibliographic source:
- Critical Review of Hydrolysis of Organic Compounds in Water Under Environmental Conditions
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: reliable literature source and QSAR
- Deviations:
- no
- Principles of method if other than guideline:
- reliable literature source and QSAR
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-chloro-2-methylpropane
- EC Number:
- 208-066-4
- EC Name:
- 2-chloro-2-methylpropane
- Cas Number:
- 507-20-0
- Molecular formula:
- C4H9Cl
- IUPAC Name:
- 2-chloro-2-methylpropane
- Details on test material:
- reliable literature source and QSAR
Constituent 1
Results and discussion
Dissipation DT50 of parent compound
- pH:
- 7
- Temp.:
- 298 K
- Hydrolysis rate constant:
- 0.03 s-1
- DT50:
- 0.383 min
Any other information on results incl. tables
form literature review the rate constant kN is 6.36E-3 per sec at 287.2 K and pH 7. The rate constant depends on
formula: log kN = -delta H/RT + delta S/R + log T + 10.32
T= 287.2 K
kN= 6.36 +/- 0.03*10E-3 s-1
delta H = 91.8 kJ/mol
10*E3 delta S = 34.8 kJ/mol K
R = 0.01914 kJ/mol K
rate constants kN, with temperature coefficients at 323.2 K
Citation of page 390
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- literature source and QSAR
- Conclusions:
- The substance tert. Butylchloride should be fast hydrolysible under environmental conditions according to the reliable literature source and QSAR.
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