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Short-term toxicity to aquatic invertebrates

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Description of key information

The acute toxic effects of EDDHMA-Fe to Daphnia magna were investigated according to the principles of OECD-Guideline 202 and EU method C.2. 
The EC50 for a 48 hour exposure was 4.6 g/L based on the study with EDDHMA-Fe which provides a true EC50 value (Thun, 1990)

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
4.6 g/L

Additional information

- Key study by Thun, 1990 :

Concentrations tested were 1.0, 1.4, 1.9, 2.6, 3.6, 5.1, 7.1 and 10 g/L EDDHMA-FeK based on a preliminary test. The 48 hour EC50 was determined at 4.6 g/L test substance, with 95% confidence intervals between 4.12 and 6.0 g/L. Due to strong coloration by the test substance only a 48h assessment was done.

Since this study provides a true EC50 and is of equal or highest reliability, it is preferred over the other studies to be considered key.

- Supporting study by Bogers, 1992 :

Under the conditions of the study EDDHMA-FeNa did not induce significant acute immobilization of Daphnia magna at or below 1000 mg/L after 48 hours of exposure. Hence, the 48h-EC50 was greater than 1000 mg/L, being the No Observed Effect Level (NOEC) for mobility of Daphnia magna.

- Supporting study by Basf 2010 :

In the study the acute toxic effects of EDDHA-FeNa to Daphnia magna were determined according to the principles of OECD-Guideline 202 and EU method C.2. A limit test with a nominal concentration of 120 mg/L was carried out at a static system. The EC50 for a 48 hour exposure was greater than 120 mg/L based on the nominal concentration of the test substance and greater than 122 mg/L based on the mean measured concentrations.

- Additionally, a study investigating the acute toxicity of EDDHMA-Na4 is given (Engstrom, 1986) as supporting evidence that these similar chelate structures have no high acute toxicity to daphnids. In this study the EC50 (96h) proved > 1200, but < 2400 mg/L the highest concentration tested at which 100% mortality was observed. No clear EC50 could be determined.

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