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EC number: 907-870-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 24 hour occlusive exposure with observations at 24 and 48 hours after start of exposure.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,4-bis(2-methylpropyl) butanedioate; 1,5-bis(2-methylpropyl) pentanedioate; 1,6-bis(2-methylpropyl) hexanedioate
- EC Number:
- 907-870-9
- Molecular formula:
- Diisobutyl succinate: C12O4H22 Diisobutyl glutarate: C13O4H24 Diisobutyl adipate: C14O4H26
- IUPAC Name:
- 1,4-bis(2-methylpropyl) butanedioate; 1,5-bis(2-methylpropyl) pentanedioate; 1,6-bis(2-methylpropyl) hexanedioate
- Test material form:
- liquid
- Details on test material:
- Mix of Diisobutyl esters:
34% Diisobutyl succinate
55% Diisobutyl glutarate
11% diisobutyl adipate
Overall purity 99.94%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 ml of the pure substance
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 48 hours
- Number of animals:
- 6 (male)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0.83
- Max. score:
- 2
- Remarks on result:
- probability of mild irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0.33
- Max. score:
- 1
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0.17
- Max. score:
- 1
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Irritant / corrosive response data:
- Erythema:
At 24 hours 2 animals had no reaction, 3 had a slight reaction and 1 had a mild reaction
At 48 hours 4 animals had no reaction and 2 animals had a slight reaction
Edema
At 24 hours 1 animal had a slight reaction and 5 had no reaction
At 48 hours no animals had reactions.
This substance therefore produced minimal irritation in 6 animals after a very conservative 24 hour occlusive exposure. As such it is not considered an irritant according to the EU classification and labelling criteria.
Any other information on results incl. tables
Erythema:
At 24 hours 2 animals had no reaction, 3 had a slight reaction and 1 had a mild reaction
At 48 hours 4 animals had no reaction and 2 animals had a slight reaction
Edema
At 24 hours 1 animal had a slight reaction and 5 had no reaction
At 48 hours no animals had reactions.
This substance therefore produced minimal irritation in 6 animals after a very conservative 24 hour occlusive exposure. As such it is not considered an irritant according to the EU classification and labelling criteria.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Conclusions:
- This substance produced minimal irritation in 6 animals after a 24 hour occlusive exposure. As such it is not considered an irritant according to the EU classification and labelling criteria.
- Executive summary:
Doses of 0.1ml of test compound applied to intact skin of rabbits under 1 1/2 inch by 1 1/2 inch, 12 -ply gauze squares. Rubber sheeting was then loosely wrapped around the trunk and secured with tape. After 24 hours the rabbits were removed from the stocks, the patches taken off and the reactions observed. Observations were also made at 48 hours. Erythema and edema were scored qualitatively as negative, slight, mild, moderate or severe.
This substance produced minimal irritation in 6 animals after a 24 hour occlusive exposure. As such it is not considered an irritant according to the EU classification and labelling criteria.
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