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EC number: 285-206-0 | CAS number: 85049-36-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- from 1984-05-17 to 1984-08-08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: 1a : the study is closely comparable to OECD guideline 401 and is GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: AFNOR NF T 03-021
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Fatty acids, C16-18 and C18-unsatd., Me esters
- EC Number:
- 267-015-4
- EC Name:
- Fatty acids, C16-18 and C18-unsatd., Me esters
- IUPAC Name:
- 267-015-4
- Details on test material:
- - Name of test material : metiloil A
- Physical state : yellow liquid
- Storage condition of test material : at room temperature
- Composition of test material, percentage of components : mixture of methyl esters of saturated and insaturade C16 to 18 fatty acids, no data
- Lot/batch No : 1169
- Acid number : 7 mgKOH/g
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Sprague-Dawley/ Crl : CD (SD) BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source : Charles River France (76410 Saint Aubin les Elbeuf, France)
- Age at study initiation : no data
- Weight at study initiation : 206g (males and 198 g ( females)
- Fasting period before study : 17h to 17h20
- Housing : in groups of 5 in polycarbonate cage (42.0 x 27.0 x 15.0)
- Diet (e.g. ad libitum) : pelleted standard n°1 Expanded SQC rat/mouse maintenance diet (Special Diets Services, Witham, Essex, U.K.), ad libitum
- Water (e.g. ad libitum) : filtrated water with F.G. millipore membrane (0.2 µ), ad libitum
- Acclimation period : 7days
ENVIRONMENTAL CONDITIONS
- Temperature (°C) : 21 +/- 3°C
- Humidity (%) : 50% +/- 20 %
- Ait changes (er hr) : no data
- Photoperiod (hrs dark/hrs light) : 12 hrs dark/12 hrs light
IN-LIFE DATES : no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICULE : No vehicule
MAXIMUM DOSE VOLUME APPLIED : 10 mg/kg bw - Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 animalsp er sex per dose
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration : 14 days
-Frequency of observations wheighing :
mortality and clinical signs : daily after admnistration
body weight : days 0, 4, 7, 14
- Necropsy of survivors performed : yes
- Other examinations performed : macroscopic examination - Statistics:
- No
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No mortality at 5000 mg/kg bw
- Clinical signs:
- other: From 10 minutes to 3 hours after administration, hypokinesia were noticed in all animals. No clinical signs from 3 hours to day 14.
- Gross pathology:
- No macroscopic findings were recarded at necroscopsy
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Metiloil A was not considered to be an acute oral toxic
- Executive summary:
In an acute oral toxicity study (Kaysen A., 1984), groups of fasted, Sprague-Dawley Crl rats ( 5 males and 5 females) were given a single oral dose of metiloil A (batch no. 1169) at dose of 5000 mg/kg bw and oserved for 14 days. Oral LD0 (combined sex) is greater than 5000 mg/kg bw (limit test). no mortality was observed. From 10 minutes to 3 hours after administration, hypokinesia were noticed in all animals. then, no clinical signs were observed. No effect on body weight was observed at the end of the observation period. Metiloil A is not classified based on the LD50 combined sex. this acute oral toxicity is classified as acceptable. It does classified the guideline requirement (OECD 401) for an acute oral study in the rats.
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