Registration Dossier
Registration Dossier
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EC number: 206-200-6 | CAS number: 307-35-7
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The experimental study is referred to PFOS (Perfluorooctane sulfonic acid). The substance RM90 is a salt of PFOS.
Data source
Reference
- Reference Type:
- publication
- Title:
- ENVIRONMENTAL AND HEALTH ASSESSMENT OF PERFLUOROOCTANE SULFONIC ACID AND ITS SALTS
- Author:
- 3M
- Year:
- 2 003
- Bibliographic source:
- Various sources listed in the assessment report.
- Report date:
- 2003
Materials and methods
Test guideline
- Guideline:
- other: no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Heptadecafluorooctane-1-sulphonic acid
- EC Number:
- 217-179-8
- EC Name:
- Heptadecafluorooctane-1-sulphonic acid
- Cas Number:
- 1763-23-1
- IUPAC Name:
- 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 90-day
Doses / concentrations
- Remarks:
- Doses / Concentrations:
30, 100, 300, 1000 and 3000 ppm
Basis:
no data
Results and discussion
Results of examinations
- Details on results:
- At 30 ppm mean body weights were slightly lower when compared to the controls, and slight elevation of blood glucose, serum alkaline phosphatase, blood urea nitrogen and gamma-glutamyl transpeptidase activities were reported.
PFOS at doses of 100 ppm and greater caused liver enzyme elevations, hepatic vacuolization, hepatocellular hypertrophy, weight loss, convulsions and death.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- < 30 ppm
- Based on:
- not specified
- Sex:
- not specified
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- NOAEL None - the lowest dose tested (30 ppm) was an effect dose.
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