4,4'-Isopropylidenediphenol, polymer with 1-chloro-2,3-epoxypropane, propane-1,2-diol acrylate and succinic anhydride

Biodegradation in water and sediment: simulation tests

Administrative data

Endpoint:

biodegradation in water: simulation testing on ultimate degradation in surface water

Data waiving:

study technically not feasible

Justification for data waiving:

the study does not need to be conducted because the substance is highly insoluble in water

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From 17 March, 2004 to 30 April, 2004

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

> 0.007 mg/L

Temp.:

19.9 °C

pH:

ca. 6.3

Details on results:

-Preliminary test: Test substance was stirred with double distilled water for 2 d at 20.4 ± 0.5°C (nominal concentration was 0.782 g/L). The concentration of the test substance in the aqueous phase after two and three successive times of centrifugation (25658 g, 5 min. and 20°C) was 0.308 mg/L and 0.181 mg/L, respectively. Because test substance is a liquid, the column elution method was not applicable. Therefore the flask method was chosen for the determination of the water solubility. The pH of the aqueous phase after 3 centrifugation steps was 6.3.
-Main study (flask method)
Test substance was stirred with double distilled water (in triplicate) at a nominal concentration of approx 2.43x10-3 g/L. Duplicate samples were taken from each water mixture after 24, 48 or 72 h of stirring. Undissolved test substance was removed by two successive centrifugation steps (25658 g, 5 min., 20°C). The aqueous phases were analysed. The temperature of the climate room was 19.9 ± 0.5°C during the performance of the test. The results for the samples were taken. The calculations were performed using not-rounded concentrations. Therefore, some differences might be observed when recalculating the mean values. No test substance was measured in the pretreated samples from the blank water mixture. One of the 72 h stirred water sample was also centrifuged a third time. Because no significant difference was observed between the concentrations analysed after the second centrifugation step (<7x10-6 g/L) and third centrifugation step (<7x10-6 g/L), it was concluded that all undissolved test substance had been removed after two centrifugation steps.

Results of the main study:

Stirring times (h)	Concentration analyzed (g/L)^2	pH^1
24	<LOD/<LOD^3	7/7
48	<LOD/<LOD^3	7/7
72	<LOD/<LOD^3	7.1/7.1

¹Measured from the aqueous phase after two centrifugation steps. The aqueous phase was diluted by a factor of 1.11 with 0.1 M sodium chloride prior to pH measurement.

²Duplicate samples.

³LOD=7x10^-6g/L.

Conclusions:

Under the conditions of the study, the water solubility of the substance at 19.9 ± 0.5⁰C was <7 x 10-3 mg/L.

Executive summary:

A study was conducted to determine the water solubility of the test substance using the shake flask method according to OECD Guideline 105 and EU method A.6, in compliance with GLP. Under the conditions of the study, the water solubility at 19.9 ± 0.5 ⁰C was < 7 x 10^-3 mg/L (Baltussen, 2004).

Results and discussion

Transformation products:

not measured