Registration Dossier

Administrative data

Endpoint:
dermal absorption
Type of information:
other: Expert assessment derived from available information
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Absorption in different matrices:
The rate and extent of absorption cannot be elucidated from the data available.

Any other information on results incl. tables

Read-across justification - A document which justifies the read–across from Cashew (Anacardium occidentale) Nutshell Extract, Decarboxylated, Distilled (“Distilled Grade”) to Cashew (Anacardium occidentale) Nutshell Extract, Decarboxylated, Distillation Residue (“Distilled Residue Grade”) is attached in the endpoint summary.

The rate and extent of absorption cannot be elucidated from the data available. Local effects only were observed from an acute dermal toxicity study, and also a skin irritation and sensitisation studies. Therefore, an indication of absorption has been observed from the sensitisation study. It is likely that the skin barrier will be compromised by the irritation/sensitisation observed following application of Cashew Nutshell Extract, Decarboxylated, Distilled (Distilled Grade), and that some absorption via this route will occur.

Applicant's summary and conclusion