Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 214-269-9 | CAS number: 1118-84-9
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- sub-chronic toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- other: study report
- Title:
- European Union Risk Assessment Report : ETHYL ACETOACETATE
- Author:
- EU Report
- Year:
- 2 002
- Bibliographic source:
- European Union risk assessment report (Ethyl acetoacetate) Vol:13 (2002) p98
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from European Union Risk assesment Report.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethyl acetoacetate
- EC Number:
- 205-516-1
- EC Name:
- Ethyl acetoacetate
- Cas Number:
- 141-97-9
- Molecular formula:
- C6H10O3
- IUPAC Name:
- ethyl 3-oxobutanoate
Constituent 1
Test animals
- Species:
- other: human
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 28 days
- Frequency of treatment:
- daily
Results and discussion
Effect levels
- Dose descriptor:
- dose level:
- Effect level:
- 420 other: mg/day
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: It suggests that systemic health risks due to repeated dermal exposure are not expected
- Remarks on result:
- other: not specified
Target system / organ toxicity
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
- Treatment related:
- not specified
- Dose response relationship:
- not specified
- Relevant for humans:
- not specified
Applicant's summary and conclusion
- Conclusions:
- In a study on ethyl acetoacetate, repeated dermal exposure of 420 mg/day suggested that systemic health risks due to repeated dermal exposure are not expected.
- Executive summary:
In a study on ethyl acetoacetate, repeated dermal exposure of 420 mg/day suggested that systemic health risks due to repeated dermal exposure are not expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
