Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
RTECS Number: ES5775000
Author:
RTECS database
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances):- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 15,613,1977
Reference Type:
review article or handbook
Title:
DOSE No.: A77
Author:
RSC Publishing
Year:
2011
Bibliographic source:
Dictionary of Substances and their effects (DOSE):- Opdyke, D. L. J. Food Cosmet. Toxicol. 1977, 15, 611
Reference Type:
review article or handbook
Title:
DPIM: AFY250
Author:
Richard J. Lewis, Sr.
Year:
2007
Bibliographic source:
SAX (Sax's Handbook of Dangerous Industrial Materials):- Food and Cosmetics Toxicology. 15 (1977), 611.
Reference Type:
other: Authoritative data base
Title:
GCID: 141749
Author:
ACToR Database
Year:
2011
Bibliographic source:
ACToR (Aggregated Computational Toxicology Resource):- Food and Cosmetics Toxicology. Vol. 15, Pg. 613, 1977.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
standard acute method
GLP compliance:
not specified
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
530 other: mg/kg
Based on:
test mat.
Remarks on result:
other: Details of toxic effects not reported other than lethal dose value

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 value of the substance allyl butyrate wass found to be 530 mg/kg body weight in rabbit.
Executive summary:

The LD50 value of the substance allyl butyrate is found to be 530 mg/kg body weight in rabbit. This classifies the chemical as being toxic in the toxicity category III as per the CLP criteria.