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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
DOSE No: M152
Author:
RSC Publishing
Year:
2011
Bibliographic source:
Dictionary of Substances and their effects (DOSE):- Romashov, P. G. et al Gig. Sanit. 1991, (3), 20-22 (Russ.) (Chem. Abstr. 115, 200734x).; Smyth, H. F. et al J. Ind. Hyg. Toxicol. 1948, 30, 63.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from DOSE.
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl acetoacetate
EC Number:
203-299-8
EC Name:
Methyl acetoacetate
Cas Number:
105-45-3
Molecular formula:
C5H8O3
IUPAC Name:
Methyl acetoacetate

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
other animals tested: rat, rabbit

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 250 - 3 500 other: mg/kg
Based on:
test mat.
Remarks on result:
other: other details not available

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 value for oral exposure of methyl acetoacetate is found to be 1250-3500 mg/kg in the various species used in the study.
Executive summary:

The LD50 value for oral exposure of methyl acetoacetate is found to be 1250-3500 mg/kg in the various species used in the study.