Registration Dossier
Registration Dossier
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EC number: 214-269-9 | CAS number: 1118-84-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- DOSE No: M152
- Author:
- RSC Publishing
- Year:
- 2 011
- Bibliographic source:
- Dictionary of Substances and their effects (DOSE):- Romashov, P. G. et al Gig. Sanit. 1991, (3), 20-22 (Russ.) (Chem. Abstr. 115, 200734x).; Smyth, H. F. et al J. Ind. Hyg. Toxicol. 1948, 30, 63.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from DOSE.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Methyl acetoacetate
- EC Number:
- 203-299-8
- EC Name:
- Methyl acetoacetate
- Cas Number:
- 105-45-3
- Molecular formula:
- C5H8O3
- IUPAC Name:
- Methyl acetoacetate
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- other animals tested: rat, rabbit
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 250 - 3 500 other: mg/kg
- Based on:
- test mat.
- Remarks on result:
- other: other details not available
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 value for oral exposure of methyl acetoacetate is found to be 1250-3500 mg/kg in the various species used in the study.
- Executive summary:
The LD50 value for oral exposure of methyl acetoacetate is found to be 1250-3500 mg/kg in the various species used in the study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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