Registration Dossier

Administrative data

Endpoint:
dermal absorption
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Authoritative data base
Title:
Danish QSAR study for CAS No.: 1118-84-9
Author:
Danish EPA Model
Year:
2012
Bibliographic source:
QSAR predictions by Danish Environmental Protection Agency (EPA)model powered by OASIS database; EPI Suite (DERMWIN) Various versions of EPI Suite dating back from 1990-2004. Equation 6 (modified

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Data is from DEPA QSAR database
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: allyl acetoacetate
- Molecular formula: C7H10O3
- Molecular weight: 142.16
- Substance type: Organic
Radiolabelling:
not specified

Test animals

Species:
other: no data
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified

Results and discussion

Percutaneous absorption
Remarks on result:
other: Dermal absorption: 0.02200 mg/cm2/event (MODERATE)

Applicant's summary and conclusion

Conclusions:
Dermal absorption value of allyl acetoacetate is estimated to be 0.02200mg/cm2/event (Moderate).
Executive summary:

Dermal absorption value of allyl acetoacetate is estimated to be 0.02200mg/cm2/event (Moderate).