Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1982
Reference Type:
secondary source
Title:
SIDS Category of Alkyl sulfates, Alkane sulfonates and Alpha-olefin sulfonates
Author:
OECD
Year:
2007
Bibliographic source:
UNEP Publications

Materials and methods

Principles of method if other than guideline:
Method: other
GLP compliance:
not specified
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test materail (as cited in study report): trade name
- Physical state: No data
- Analytical purity: 55% a.i.
- Lot / batch No.: No data
- Storage conditions of test material: No data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
3160, 3980, 5010, 5320, 5630, 6250 and 7000 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
no

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
5 500 mg/kg bw
Based on:
act. ingr.

Any other information on results incl. tables

LD50 range: 5000 - 6050 mg/kg

MORTALITY:
-Time of death: 2 hrs - 2 days
-Number of deaths at each dose: 0/10, 1/10, 3/10, 5/10, 6/10, 7/10 or 10/10

CLINICAL SIGNS: diarrhoea, piloerection, increased breathing

NECROPSY FINDINGS: no adverse effects at macroscopic examination

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU