Registration Dossier

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Article of limited reporting; in French
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH
Available data from Lauryloxypropylamine (Etheramine C12) are considered to be applicable for Etheramine C10i as well. The structure of Etheramine C12 only differs from that of Etheramine C10i, in that the alkyl chain is only 2 carbons longer. This only has limited effects on physical properties, whereas chemical behaviour, reactivity and metabolism are the same.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1985

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Results and discussion

Applicant's summary and conclusion

Conclusions:
Etheramine C12 is in rabbits rapidly distributed and quickly excreted mainly via urine with T1/2 of about half an hour. The data also suggest a quick metabolization.
Executive summary:

SUMMARY. - Lauryloxypropylamine dosage in blood and urines is carried out by fluorimetry after HPLC separation, with dodecylamine as internal standard. Standard curve is linear till lauryloxypropylamine injection of 200 ng. Detection limit is of nearly 5 ng/injection. Lauryloxypropylamine pharmacokinetic study was carried out on rabbits with rapid intravenous administration of a 5 mg/kg dose. Different experimental curves obtained after blood and urine sampling and mathematic analysis allow to describe lauryloxypropylamine behaviour through the organism following an open pharmacokinetic model with two distribution compartments. Elimination half-life calculated time is of 29 mn and distribution volume of 13.37 I/kg.