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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Description of key information

The EC50parental mortality is 1.09 mg/L river water based on test material, derived from the 21d-daphnia test according to OECD TG 211 (GLP, Reliability 1). The 21d EC50 parental mortality is 1.05 mg/L river water converted to active ingredient.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
1.05 mg/L

Additional information

The long term 21d-EC50 for parental mortality determined in the OECD 211 test with river water (reliability 1) was used as the key value for acute toxicity for daphnia in the chemical safety assessment. The study was assigned reliability 1 as all validation criteria were fulfilled (GLP,complete identification of test substance, including chemical analyses). The effects are expressed as nominal values because the tests were performed with river water. The substance is known for its poor water solubility and tendency to adsorb onto organic matter in test media. Therefore it was decided to perform higher tier chronic invertebrate studies with analytical monitoring of the test concentrations. These higher tier tests were performed in river water to allow a PECaquatic,bulk / PNECaquatic,bulk approach for the environmental risk assessment. Further experimental details of the key study are described in the section on long term toxicity to aquatic invertebrates.

A range finding study for acute immobilization is available for the substance (non GLP).

The acute immobilisation was assessed in a non GLP preliminary range finding test conducted at the same test facility as the long term test under static conditions over a period of 48 hours. Three concentration levels of the test item of 1, 10 and 100 mg/L were tested under the same conditions as specified for the definitive long term test. 100% immobilisation was observed at the test concentration of 10 mg/L, while no immobilisation was observed at the test concentration of 1 mg/L after 48h. The results of the range finding study confirm that the 21d EC50 of 1.05 mg/L is a worst case representation of acute immobilisation.