Registration Dossier
Registration Dossier
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EC number: 220-150-2 | CAS number: 2643-07-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- Method: other: according to Smyth H. F. et al. Am. Ind. Hyg. Ass. J. 23, 95-107, 1962
- GLP compliance:
- no
- Test type:
- other: Inhalation Risk Test
Test material
- Reference substance name:
- p-[(2-chloroethyl)ethylamino]benzaldehyde
- EC Number:
- 220-150-2
- EC Name:
- p-[(2-chloroethyl)ethylamino]benzaldehyde
- Cas Number:
- 2643-07-4
- Molecular formula:
- C11H14ClNO
- IUPAC Name:
- 4-[(2-chloroethyl)(ethyl)amino]benzaldehyde
- Details on test material:
- N-Ethyl-N-(2-chlorethyl)-p-amino-benzaldehyd (purity > 90 %)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Temperature in air chamber: 20°C
- Duration of exposure:
- 7 h
- Concentrations:
- 1.68 mg/l
- No. of animals per sex per dose:
- 12 animals
- Details on study design:
- 12 animals were exposed to an atmosphere that was enriched with the test substance. Therefore 200 l air/h were conducted through a 5 cm high layer of the test substance at 20°C.
Results and discussion
Effect levels
- Dose descriptor:
- LC50
- Effect level:
- > 1.68 mg/L air
- Exp. duration:
- 7 h
- Remarks on result:
- other: no mortality
- Mortality:
- No mortality occured after 7 h exposure to the test substance.
- Clinical signs:
- other: No symptoms were observed.
- Gross pathology:
- Nothing abnormal detected during dissection.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
