Registration Dossier
Registration Dossier
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EC number: 220-290-4 | CAS number: 2702-72-9
Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Justification for classification or non-classification
Additional information
For sodium 2,4-dichlorophenoxyacetate there are no data available for carcinogenicity.
According to the Reach regulation (1907/2006/EC), a carcinogenicity study may be proposed by the registrant or may be required by the Agency in accordance with Articles 40 or 41 if the substance has a widespread dispersive use or there is evidence of frequent or long-term human exposure, and the substance is classified as mutagen category 3 or there is evidence from repeated dose studies that the substance is able to induce hyperplasia and/or pre-neoplastic lesions.
There is no evidence, that the test material sodium 2,4-dichlorophenoxyacetate causes carcinogenicity by a direct genotoxic mechanism as the results of all genotoxicity studies (mutagenicity and cytogenicity) were negative. In the 90-day repeated dose toxicity study no evidence for hyperplasia or preneoplastic lesions was seen.
Thus, the proposal for a carcinogenicity study would be scientifically unjustified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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