Registration Dossier

Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
other: read across from 2,2,6,6 -tetramethylpiperidin-4 -ol (the analogue substance with no methyl group on N)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
See the summary of this endpoint

Data source

Reference
Reference Type:
review article or handbook
Title:
OECD SIDS 2,2’,6,6’-TETRAMETHYLPIPERIDIN-4-OL
Author:
OECD
Year:
2002
Bibliographic source:
OECD SIDS 2,2,6,6-Tetramethylpiperidin-4-ol (CAS 2403-88-5)
Report Date:
2002

Materials and methods

Test guideline
Guideline:
OECD Guideline 406 (Skin Sensitisation)
GLP compliance:
not specified
Type of study:
other: read across
Justification for non-LLNA method:
Available (older) study

Test material

Reference
Name:
Unnamed
Type:
Constituent

In vivo test system

Test animals

Species:
guinea pig

Results and discussion

In vivo (non-LLNA)

Results
Reading:
other: skin sensitisation score
Group:
test group
Dose level:
0
No. with + reactions:
0
Total no. in group:
0
Clinical observations:
This substance is classified as a moderate to strong sensitizer in albino guinea pigs according to the grading of Magunusson and Kligman.
Remarks on result:
positive indication of skin sensitisation

Applicant's summary and conclusion

Interpretation of results:
sensitising