Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irreversible damage)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin irritation/corrosion

The SDS from Acros refers to corrosive (C;R34) based on an OECD TG404 study with necrosis after 60 minutes

2,2,6,6 -tetramethylpiperidin-4 -ol (the analogue substance with no methyl group on N) is highly irritating in an OECD TG404 study

The OECD toolbox study finds this substance irritating

Conclusion: the substance is C;R34 (conservative approach), which translates under GHS to Corrosive Category 1 with pictogram GHS05 (corrosion), signalword Danger and H314: Causes severe skin burns and eye damage

Eye irritaion/corrosion

Only the OECD toolbox v3.4 study is available. This finds the substance irritating


Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: highly corrosive

Justification for classification or non-classification

The substance must be classified as corrosive to skin and eye Category 1 with pictogram GHS05 (corrosion), signalword Danger and H314: Causes severe skin burns and eye damage