Registration Dossier
Registration Dossier
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EC number: 231-780-2 | CAS number: 7727-18-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
In accordance with REACH Annex XI, section 2, testing is technically not feasible as a consequence of the properties of the substance (hydrolytically unstable substance and quasi-instantaneously degraded in contact with moist skin or mucuous membranes to form Vanadium pentoxide and hydrogen chloride). There are sufficient data on the cleavage products (Vanadium pentoxide and hydrogen chloride were already registered in the frame of REACH) and the breakdown substance are exempted to Registration following Annex V (Entry I).
Genetic toxicity in vivo
Description of key information
In accordance with REACH Annex XI, section 2, testing is technically not feasible as a consequence of the properties of the substance (hydrolytically unstable substance and quasi-instantaneously degraded in contact with moist skin or mucuous membranes to form Vanadium pentoxide and hydrogen chloride). There are sufficient data on the cleavage products (Vanadium pentoxide and hydrogen chloride were already registered in the frame of REACH) and the breakdown substance are exempted to Registration following Annex V (Entry I).
Link to relevant study records
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Vanadium trichloride oxide quasi-instantaneously degraded in contact with moist skin or mucuous membranes to form Vanadium pentoxide and hydrogen chloride.
Testing Vanadium trichloride oxide for genetic toxicity is for this reason not relevant at all, but breakdown products have to be considered (classification for Vanadium pentoxide and hydrogen chloride have been elaborated in the frame of REACH).
For these reasons, no classification could be set for genetic toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
